Toh Han Wei

Drug coated balloons (DCBs) are largely used in peripheral artery disease (PAD) or for treatment of in-stent restenosis (ISR). DCBs are angioplasty balloons coated with a layer of anti-proliferative drug mixed with an excipient, to enhance drug persistence during tracking and drug transfer onto lesion. However, the efficacy of DCBs are very much linked to the matrix or carrier that holds the anti-proliferative drug. Hence, there is a desire to create an excipient with robust coating persistence for tracking while still achieving maximal drug transfer onto the lesion site. Other research involvement would include the development of Fractional Flow Reserve - Computed Tomography (FFR-CT). FFR is determine through an invasive method, by inserting a pressure wire to the lesion site, to determine if the lesion is functionally significant. However, with the implementation of lumen segmentation obtained from CT scans and computational fluid dynamics modelling, we can obtain FFR values without an invasive method. Thus, FFR-CT is an attractive idea for clinical adoption to reduce healthcare cost and burden.